In a computer system supporting execution of virtualization software and at least one instance of virtual system hardware, an interface is provided into the virtualization software to allow a program to directly define the access characteristics of its program data stored in physical memory. The technique includes providing data identifying memory pages and their access characteristics to the virtualization software which then derives the memory access characteristics from the specified data. Optionally, the program may also specify a pre-defined function to be performed upon the occurrence of a fault associated with access to an identified memory page. In this manner, programs operating both internal and external to the virtualization software can protect his memory pages, without intermediation by the operating system software.