A memory system, having indeterminate read data latency, that includes a memory controller and one or more hub devices. The memory controller is configured for receiving data transfers via an upstream channel and for determining whether all or a subset of the data transfers include a data frame by detecting a frame start indicator. The data frame includes an identification tag that is utilized by the memory controller to associate the data frame with a corresponding read instruction issued by the memory controller. The one or more hub devices are in communication with the memory controller in a cascade interconnect manner via the upstream channel and a downstream channel. Each hub device is configured for receiving the data transfers via the upstream channel or the downstream channel and for determining whether all or a subset of the data transfers include a data frame by detecting the frame start indicator.