Systems and methods for multi-user interference cancellation are provided. In one aspect of the disclosure, an apparatus is provided. The apparatus comprises a processing unit configured to process received chips into received symbols for a plurality of users and a detection unit configured to detect user symbols from the received symbols. The apparatus also comprises an interference cancellation unit configured to compute multi-user interference using the detected user symbols and to remove the computed multi-user interference from the received symbols. The apparatus further comprises a redetection unit configured to redetect user symbols from the received symbols with the computed multi-user interference removed.