Invention Grant
- Patent Title: Hydrophilic vehicle-based dual controlled release matrix system
- Patent Title (中): 亲水性车载双控制基质系统
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Application No.: US11553356Application Date: 2006-10-26
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Publication No.: US08333989B2Publication Date: 2012-12-18
- Inventor: Karunakar Sukuru
- Applicant: Karunakar Sukuru
- Applicant Address: US NC High Point
- Assignee: Banner Pharmacaps, Inc.
- Current Assignee: Banner Pharmacaps, Inc.
- Current Assignee Address: US NC High Point
- Agency: Pabst Patent Group LLP
- Main IPC: A61K9/66
- IPC: A61K9/66

Abstract:
A hydrophilic vehicle-based dual controlled-release matrix system, suitable for encapsulation in hard or soft capsules, has been developed. The matrix is in the form of a solution or a suspension, which allows for easier formulation of low dose compounds. The matrix includes two rate controlling barriers for the controlled release of one or more pharmaceutically active agents. The primary rate controlling barrier includes a hydrophilic vehicle. The primary rate controlling barrier can further comprise one or more solvents which are miscible with the hydrophilic vehicle. The secondary rate controlling barrier includes a hydrogel-forming polymeric material dissolved or dispersed in the hydrophilic vehicle. The presence of the hydrogel-forming polymeric material makes extraction of the drug from the dosage form more difficult. This feature could be beneficial in preventing or minimizing the misuse of dosage forms which contain drugs which are prone to abuse.
Public/Granted literature
- US20070098783A1 Hydrophilic Vehicle-Based Dual Controlled Release Matrix System Public/Granted day:2007-05-03
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