Invention Grant
US08334256B2 Pharmaceutical salts of macrocyclic modulators of the ghrelin receptor
有权
生长素释放肽受体的大环调节剂的药物盐
- Patent Title: Pharmaceutical salts of macrocyclic modulators of the ghrelin receptor
- Patent Title (中): 生长素释放肽受体的大环调节剂的药物盐
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Application No.: US12351395Application Date: 2009-01-09
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Publication No.: US08334256B2Publication Date: 2012-12-18
- Inventor: Eric Marsault , Carl St-Louis
- Applicant: Eric Marsault , Carl St-Louis
- Applicant Address: CA
- Assignee: Tranzyme Pharma Inc.
- Current Assignee: Tranzyme Pharma Inc.
- Current Assignee Address: CA
- Agency: Myers Bigel Sibley & Sajovec, PA
- Main IPC: A61K38/25
- IPC: A61K38/25 ; C09F1/04

Abstract:
The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and variants thereof). Methods of synthesizing the novel compounds are also described herein. These compounds are useful as agonists of the ghrelin receptor and as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, central nervous system disorders, genetic disorders, hyperproliferative disorders and inflammatory disorders.
Public/Granted literature
- US20090221689A1 Macrocyclic Modulators of the Ghrelin Receptor Public/Granted day:2009-09-03
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