Invention Grant
US08334277B2 {4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenoxy}phosphate or a pharmaceutically acceptable salt thereof, a production method therefor and a pharmaceutical composition for preventing and treating central nervous system disorders containing the same as an active component
有权
{4- [2-(二甲基氨基)-1-(1-羟基环己基)乙基]苯氧基}磷酸酯或其药学上可接受的盐,其制备方法和用于预防和治疗含有其的中枢神经系统疾病的药物组合物 活性组分
- Patent Title: {4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenoxy}phosphate or a pharmaceutically acceptable salt thereof, a production method therefor and a pharmaceutical composition for preventing and treating central nervous system disorders containing the same as an active component
- Patent Title (中): {4- [2-(二甲基氨基)-1-(1-羟基环己基)乙基]苯氧基}磷酸酯或其药学上可接受的盐,其制备方法和用于预防和治疗含有其的中枢神经系统疾病的药物组合物 活性组分
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Application No.: US12990972Application Date: 2009-05-08
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Publication No.: US08334277B2Publication Date: 2012-12-18
- Inventor: Seok Won Kang , Jong Soo Chun , Heung Mo Kang , Eui Seok Hong , Kwang-Woo Chun , Young Seok Byun , Myung-Hwa Kim , Young Il Moon , Jei Man Ryu
- Applicant: Seok Won Kang , Jong Soo Chun , Heung Mo Kang , Eui Seok Hong , Kwang-Woo Chun , Young Seok Byun , Myung-Hwa Kim , Young Il Moon , Jei Man Ryu
- Applicant Address: KR Seoul
- Assignee: JE IL Pharmaceutical Co., Ltd.
- Current Assignee: JE IL Pharmaceutical Co., Ltd.
- Current Assignee Address: KR Seoul
- Agency: Lucas & Mercanti, LLP
- Priority: KR10-2008-0043034 20080508
- International Application: PCT/KR2009/002426 WO 20090508
- International Announcement: WO2009/136756 WO 20091112
- Main IPC: A61K31/045
- IPC: A61K31/045 ; A61K31/137 ; A61K31/661 ; C07F9/12
![{4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenoxy}phosphate or a pharmaceutically acceptable salt thereof, a production method therefor and a pharmaceutical composition for preventing and treating central nervous system disorders containing the same as an active component](/abs-image/US/2012/12/18/US08334277B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to a novel {4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenoxy}phosphate or a pharmaceutically acceptable salt thereof, a production method therefor and a pharmaceutical composition for preventing and treating central nervous system disorders which contains the same as an active component. The novel {4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenoxy}phosphate or a pharmaceutically acceptable salt thereof according to the present invention can beneficially be used to prevent and treat central nervous system disorders since it exhibits an equivalent biological and pharmacological activity to venlafaxine and salts thereof which are known in the field, it has very little toxicity, and, in particular, it is outstandingly soluble in water as compared with prior-art venlafaxine derivatives.
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