The present invention discloses a GSM/CDMA dual-mode mobile phone and method of the same for inhibiting a GC mutual interference, wherein the mobile phone comprises a dual-port antenna connected respectively with a duplexer and a GSM RF circuit and configured to access the signals of the GSM and the CDMA; a RF switch provided in the CDMA RF receiving circuit, wherein the RF switch is controlled by a GSM baseband chip and configured to cut off a CDMA signal (i.e., cutting off a receiving path of the CDMA) transmitted/received by the dual-port antenna when a GSM operational frequency and a CDMA operational frequency belong to close frequency band during a transmitting timeslot of the GSM, to enhance the isolation between a GSM signal and a CDMA signal. The present invention inhibits interference of GSM transmission with the CDMA receiving in the circuit, achieves high isolation, and also simplifies design of the antennas, lowers requirements of the double antennas on the appearance and volume of the overall machine, and improves the flexibility in the design of the dual-mode mobile phone.