Methods of adjusting ink ejection characteristics of an inkjet printing apparatus and driving the inkjet printing apparatus are provided. A method of adjusting ink ejection characteristics of an inkjet printing apparatus may include adjusting at least one of a voltage and an application duration of a driving signal applied to a plurality of piezoelectric actuators that provide ejection pressures to a plurality of nozzles so that volumes of a plurality of ink droplets ejected from the plurality of nozzles are uniform, and displacing an application starting time of the driving signal applied to the plurality of piezoelectric actuators so that the plurality of ink droplets ejected from the plurality of nozzles reach a printing medium at a same time.