Invention Grant
- Patent Title: Adjuvant incorporation in immunonanotherapeutics
- Patent Title (中): 佐剂掺入免疫疗法
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Application No.: US12428395Application Date: 2009-04-22
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Publication No.: US08343498B2Publication Date: 2013-01-01
- Inventor: Frank Alexis , Matteo Iannacone , Jinjun Shi , Pamela Basto , Elliott Ashley Moseman , Ulrich von Andrian , Robert S. Langer , Omid C. Farokhzad , Elena Tonti
- Applicant: Frank Alexis , Matteo Iannacone , Jinjun Shi , Pamela Basto , Elliott Ashley Moseman , Ulrich von Andrian , Robert S. Langer , Omid C. Farokhzad , Elena Tonti
- Applicant Address: US MA Cambridge US MA Boston US MA Cambridge
- Assignee: Massachusetts Institute of Technology,The Brigham and Women's Hospital, Inc.,President and Fellows of Harvard College
- Current Assignee: Massachusetts Institute of Technology,The Brigham and Women's Hospital, Inc.,President and Fellows of Harvard College
- Current Assignee Address: US MA Cambridge US MA Boston US MA Cambridge
- Agency: Pabst Patent Group LLP
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K47/00
Abstract:
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is an adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
Public/Granted literature
- US20100129439A1 Adjuvant Incorporation in Immunonanotherapeutics Public/Granted day:2010-05-27
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