Invention Grant
- Patent Title: Method for producing an immediately decomposing oral form of administration which releases active ingredients
-
Application No.: US10542283Application Date: 2003-11-21
-
Publication No.: US08343542B2Publication Date: 2013-01-01
- Inventor: Hans-Ulrich Petereit , Christian Meier , Andreas Gryczke
- Applicant: Hans-Ulrich Petereit , Christian Meier , Andreas Gryczke
- Applicant Address: DE Darmstat
- Assignee: Evonik Roehm GmbH
- Current Assignee: Evonik Roehm GmbH
- Current Assignee Address: DE Darmstat
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: DE10304403 20030128
- International Application: PCT/EP03/13059 WO 20031121
- International Announcement: WO2004/066976 WO 20040812
- Main IPC: A61K9/20
- IPC: A61K9/20 ; B27N3/00

Abstract:
The invention relates to a method for producing an oral form of administration which decomposes immediately and releases active ingredients in the mouth. According to said method, (a) an anionic pharmaceutical active ingredient is intensively mixed with (b) a copolymer consisting of radically polymerized C1-C4 esters of the acrylic acid or methacrylic acid and other (meth)acrylate monomers containing functional tertiary amino groups, and (c) between 5 and 50 wt. %, in relation to (b), of a C12-C22 carboxylic acid in the melted mass; the mixture is solidified and ground to form a powder containing active ingredients having an average particle size of 200 μm or less; and the powder is encapsulated in a water-soluble matrix consisting of pharmaceutically standard adjuvants, on the condition that no more than 3 wt. %, in relation to the copolymer, of emulsifiers with an HLB value of at least 14 must be contained therein. The invention also relates to the powder containing active ingredients and the uses of the same.
Public/Granted literature
Information query