Invention Grant
- Patent Title: Solid dosage form comprising solid dispersion
- Patent Title (中): 包含固体分散体的固体剂型
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Application No.: US11888445Application Date: 2007-08-01
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Publication No.: US08343547B2Publication Date: 2013-01-01
- Inventor: Takafumi Hoshino , Fumie Kusaki , Naosuke Maruyama , Yuichi Nishiyama , Ikuo Fukui , Hiroshi Umezawa
- Applicant: Takafumi Hoshino , Fumie Kusaki , Naosuke Maruyama , Yuichi Nishiyama , Ikuo Fukui , Hiroshi Umezawa
- Applicant Address: JP
- Assignee: Shin-Etsu Chemical Co., Ltd.
- Current Assignee: Shin-Etsu Chemical Co., Ltd.
- Current Assignee Address: JP
- Agency: Myers Bigel Sibley & Sajovec, PA
- Priority: JP2006-215401 20060808; JP2006-287859 20061023
- Main IPC: A61K9/14
- IPC: A61K9/14 ; A61K9/50

Abstract:
Provided are a solid dosage form comprising a solid dispersion that allows a drug in the preparation to be rapidly dissolved without compromising the solubility of the solid dispersion, and a method for producing the same. More specifically, provided is a solid dosage form comprising a solid dispersion, the dispersion comprising: a poorly soluble drug, a water-soluble polymer and a disintegrant, wherein the disintegrant is low-substituted hydroxypropylcellulose having an average particle size of 10 to 100 μm and a specific surface area measured by BET method of at least 1.0 m2/g. Moreover, provided is a method for producing a solid dosage form comprising a solid dispersion, the method comprising steps of: spraying a water-soluble polymer solution in which a poorly soluble drug has been dispersed or dissolved, on a powder of low-substituted hydroxypropylcellulose having an average particle size of 10 to 100 μm and a specific surface area measured by BET method of at least 1.0 m2/g and serving as a disintegrant and granulating the resultant; and drying.
Public/Granted literature
- US20080038339A1 Solid dosage form comprising solid dispersion and method for producing the same Public/Granted day:2008-02-14
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