Invention Grant
- Patent Title: Polynucleotides allowing the expression and secretion of recombinant pseudo-virus containing foreign epitopes, their production, and use
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Application No.: US13037931Application Date: 2011-03-01
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Publication No.: US08343757B2Publication Date: 2013-01-01
- Inventor: Qiang Deng , Marie-Louise Michel
- Applicant: Qiang Deng , Marie-Louise Michel
- Applicant Address: FR Paris FR Paris
- Assignee: Institut Pasteur,Institut National de la Sante et de la Recherche Medicale (INSERM)
- Current Assignee: Institut Pasteur,Institut National de la Sante et de la Recherche Medicale (INSERM)
- Current Assignee Address: FR Paris FR Paris
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner L.L.P.
- Main IPC: C12N15/00
- IPC: C12N15/00 ; C12N15/09
Abstract:
This invention provides a new approach to the design of a virus with a defective replication cycle, which can be rescued by wild type virus co-infection, and which expresses foreign antigenic epitopes that contribute to the elimination of virus infected cells and then to viral clearance. The vector of the invention, by expression of epitopes derived from common pathogens, by-passes existing tolerance of virus specific T cell responses. The vector will only replicate in virus infected cells.
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