Invention Grant
US08343928B2 Monomethylvaline compounds having phenylalanine side-chain replacements at the C-terminus
有权
在C末端具有苯丙氨酸侧链替代的单甲基缬氨酸化合物
- Patent Title: Monomethylvaline compounds having phenylalanine side-chain replacements at the C-terminus
- Patent Title (中): 在C末端具有苯丙氨酸侧链替代的单甲基缬氨酸化合物
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Application No.: US11994809Application Date: 2006-07-07
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Publication No.: US08343928B2Publication Date: 2013-01-01
- Inventor: Svetlana O. Doronina , Toni Beth Kline
- Applicant: Svetlana O. Doronina , Toni Beth Kline
- Applicant Address: US WA Bothell
- Assignee: Seattle Genetics, Inc.
- Current Assignee: Seattle Genetics, Inc.
- Current Assignee Address: US WA Bothell
- Agency: Kilpatrick Townsend & Stockton LLP
- International Application: PCT/US2006/026352 WO 20060707
- International Announcement: WO2007/008603 WO 20070118
- Main IPC: A61K38/02
- IPC: A61K38/02
Abstract:
Auristatin peptide analogs of MeVal-Val-Dil-Dap-Phe (MMAF) are provided having C-terminal phenylalanine residue side chain replacements or modifications which are provided alone or attached to ligands through various linkers. The related conjugates can target specific cell types to provide therapeutic benefit.
Public/Granted literature
- US20090018086A1 Monomethylvaline Compounds Having Phenylalanine Side-Chain Replacements at the C-Terminus Public/Granted day:2009-01-15
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