Invention Grant
- Patent Title: Methods of modulating angiogenesis
- Patent Title (中): 调节血管发生的方法
-
Application No.: US12510201Application Date: 2009-07-27
-
Publication No.: US08343939B2Publication Date: 2013-01-01
- Inventor: Christian Rask Madsen , George Liang King
- Applicant: Christian Rask Madsen , George Liang King
- Applicant Address: US MA Boston
- Assignee: Joslin Diabetes Center, Inc.
- Current Assignee: Joslin Diabetes Center, Inc.
- Current Assignee Address: US MA Boston
- Agency: Pierce Atwood LLP
- Agent Joseph M. Maraia; Kevin M. Farrell
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C07H21/02 ; C07H21/04

Abstract:
The present inventors discovered that PKCε is necessary for VEGF signaling through PI3K/Akt-dependent pathways and is involved in MAPK-dependent pathways, thus regulating eNOS activity and DNA synthesis, respectively. Thus differential manipulation of PKCε activity can be used to modify VEGF effects in conditions in which modulation of angiogenesis is desirable (e.g., for treatment of diabetic proliferative retinopathy or to enhance angiogenesis for treatment of peripheral and myocardial ischemia).
Public/Granted literature
- US20100135995A1 METHODS OF MODULATING ANGIOGENESIS Public/Granted day:2010-06-03
Information query