Invention Grant
- Patent Title: Benzoxazepin PI3K inhibitor compounds and methods of use
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Application No.: US13477587Application Date: 2012-05-22
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Publication No.: US08343955B2Publication Date: 2013-01-01
- Inventor: Nicole Blaquiere , Steven Do , Danette Dudley , Adrian Folkes , Robert Heald , Timothy Heffron , Mark Jones , Aleksandr Kolesnikov , Chudi Ndubaku , Alan G. Olivero , Stephen Price , Steven Staben , Lan Wang
- Applicant: Nicole Blaquiere , Steven Do , Danette Dudley , Adrian Folkes , Robert Heald , Timothy Heffron , Mark Jones , Aleksandr Kolesnikov , Chudi Ndubaku , Alan G. Olivero , Stephen Price , Steven Staben , Lan Wang
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agent Alex Andrus
- Main IPC: A61K31/553
- IPC: A61K31/553

Abstract:
Benzoxazepin compounds of Formula I, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, wherein: Z1 is CR1 or N; Z2 is CR2 or N; Z3 is CR3 or N; Z4 is CR4 or N; and B is a pyrazolyl, imidazolyl, or triazolyl ring fused to the benzoxepin ring, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
Public/Granted literature
- US20120244149A1 BENZOXAZEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE Public/Granted day:2012-09-27
Information query
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