Invention Grant
US08343960B2 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their medical use
有权
1,4-二氮杂双环[3.2.2]壬基嘧啶衍生物及其医疗用途
![1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their medical use](/docs/US/2013-01-01/US08343960B2/abs.jpg.600x600.jpg)
- Patent Title: 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their medical use
- Patent Title (中): 1,4-二氮杂双环[3.2.2]壬基嘧啶衍生物及其医疗用途
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Application No.: US12742627Application Date: 2008-11-13
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Publication No.: US08343960B2Publication Date: 2013-01-01
- Inventor: Dan Peters , Daniel B. Timmermann , Elsebet Ostergaard Nielsen , Gunnar M. Olsen , Tino Dyhring , Jeppe Kejser Christensen , John Paul Redrobe , Jens Damsgaard Mikkelsen
- Applicant: Dan Peters , Daniel B. Timmermann , Elsebet Ostergaard Nielsen , Gunnar M. Olsen , Tino Dyhring , Jeppe Kejser Christensen , John Paul Redrobe , Jens Damsgaard Mikkelsen
- Applicant Address: DK Ballerup
- Assignee: Neurosearch A/S
- Current Assignee: Neurosearch A/S
- Current Assignee Address: DK Ballerup
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: DK200701620 20071114
- International Application: PCT/EP2008/065436 WO 20081113
- International Announcement: WO2009/062988 WO 20090522
- Main IPC: A61P25/00
- IPC: A61P25/00 ; A61K31/55 ; C07D471/08
![1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their medical use](/abs-image/US/2013/01/01/US08343960B2/abs.jpg.150x150.jpg)
Abstract:
This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters.Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
Public/Granted literature
- US20100298307A1 NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINE DERIVATIVES AND THEIR MEDICAL USE Public/Granted day:2010-11-25
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