Invention Grant
- Patent Title: Formulations containing clopidogrel and sulfoalkyl ether cyclodextrin and methods of use
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Application No.: US12597908Application Date: 2008-04-26
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Publication No.: US08343995B2Publication Date: 2013-01-01
- Inventor: Gerold L. Mosher , Rebecca L. Wedel , Karen T. Johnson , Stephen G. Machatha , Jane A. Cowee , Daniel J. Cushing
- Applicant: Gerold L. Mosher , Rebecca L. Wedel , Karen T. Johnson , Stephen G. Machatha , Jane A. Cowee , Daniel J. Cushing
- Applicant Address: US KS Lenexa
- Assignee: Cydex Pharmaceuticals, Inc.
- Current Assignee: Cydex Pharmaceuticals, Inc.
- Current Assignee Address: US KS Lenexa
- Agency: RatnerPrestia
- International Application: PCT/US2008/061697 WO 20080426
- International Announcement: WO2008/134600 WO 20081106
- Main IPC: A61K31/44
- IPC: A61K31/44

Abstract:
The present invention provides compositions containing clopidogrel, present as a free base or a pharmaceutically acceptable salt thereof, and sulfoalkyl ether cyclodextrin (SAE-CD). The compositions can be liquid, suspension or solid compositions. They can be adapted for oral, peroral or parenteral administration. The SAE-CD serves to aid in dissolution and stabilization of the clopidogrel in aqueous media. The stability of clopidogrel against hydrolytic degradation, thermal degradation, and photolytic degradation are improved. SAE-CD provides improved results over other cyclodextrin derivatives. The SAE-CD-containing composition of clopidogrel can be provided in liquid form, solid form or as a reconstitutable powder. Both ready-to-use and concentrated liquid compositions can be prepared. The liquid composition is optionally available as a clear solution. The compositions herein can be administered perorally or parenterally and provide substantial pharmacokinetic, pharmacodynamic and/or therapeutic advantages over a tablet composition administered perorally and excluding SAE-CD.
Public/Granted literature
- US20100292268A1 Formulations Containing Clopidogrel and Sulfoalkyl Ether Cyclodextrin and Methods of Use Public/Granted day:2010-11-18
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