Invention Grant
US08344005B2 5-[5-[2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoMethylpropanoylmethylamino]-4-(4-fluoro-2-methylphenyl)]-2 as NK1 receptor antagonists
有权
作为NK1受体拮抗剂的5- [5- [2-（3,5-双（三氟甲基）苯基）-2-甲基丙酰基甲基丙酰基甲基氨基] -4-（4-氟-2-甲基苯基）] -
![5-[5-[2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoMethylpropanoylmethylamino]-4-(4-fluoro-2-methylphenyl)]-2 as NK1 receptor antagonists](/docs/US/2013-01-01/US08344005B2/abs.jpg.600x600.jpg)
- Patent Title: 5-[5-[2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoMethylpropanoylmethylamino]-4-(4-fluoro-2-methylphenyl)]-2 as NK1 receptor antagonists
- Patent Title (中): 作为NK1受体拮抗剂的5- [5- [2-（3,5-双（三氟甲基）苯基）-2-甲基丙酰基甲基丙酰基甲基氨基] -4-（4-氟-2-甲基苯基）] -
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Application No.: US12991515Application Date: 2009-05-12
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Publication No.: US08344005B2Publication Date: 2013-01-01
- Inventor: Giuseppe Alvaro , Agostino Marasco
- Applicant: Giuseppe Alvaro , Agostino Marasco
- Applicant Address: SG Jurong
- Assignee: Glaxo Wellcome Manufacturing Pte Ltd
- Current Assignee: Glaxo Wellcome Manufacturing Pte Ltd
- Current Assignee Address: SG Jurong
- Agent J. Scott Young
- Priority: GB0808747.0 20080514
- International Application: PCT/EP2009/055700 WO 20090512
- International Announcement: WO2009/138393 WO 20091119
- Main IPC: A61K31/4439
- IPC: A61K31/4439 ; C07D401/04
![5-[5-[2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoMethylpropanoylmethylamino]-4-(4-fluoro-2-methylphenyl)]-2 as NK1 receptor antagonists](/abs-image/US/2013/01/01/US08344005B2/abs.jpg.150x150.jpg)
Abstract:
The invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R is C1-4 alkyl useful in the treatment of diseases and conditions for which antagonism of NK1 receptor is beneficial.
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