Invention Grant
- Patent Title: Process for preparing modulators of cystic fibrosis transmembrane conductance regulator
- Patent Title (中): 制备囊性纤维化跨膜电导调节剂的方法
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Application No.: US12909750Application Date: 2010-10-21
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Publication No.: US08344147B2Publication Date: 2013-01-01
- Inventor: Narendra Bhalchandra Ambhaikar , Robert Hughes , Dennis James Hurley , Elaine Chungmin Lee , Benjamin Littler , Mehdi Numa , Stefanie Roeper , Urvi Sheth
- Applicant: Narendra Bhalchandra Ambhaikar , Robert Hughes , Dennis James Hurley , Elaine Chungmin Lee , Benjamin Littler , Mehdi Numa , Stefanie Roeper , Urvi Sheth
- Applicant Address: US MA Cambridge
- Assignee: Vertex Pharmaceutical Incorporated
- Current Assignee: Vertex Pharmaceutical Incorporated
- Current Assignee Address: US MA Cambridge
- Agency: Honigman Miller Schwartz and Cohn LLP
- Agent Christopher C. Forbes; Jonathan P. O'Brien
- Main IPC: C07D487/08
- IPC: C07D487/08 ; C07D215/56
Abstract:
The present invention relates to processes for preparing solid state forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1, 4-dihydroquinoline-3-carboxamide, including Compound 1 Form A, Compound 1 Form A-HCl, Compound 1 Form B, and Compound 1 Form B-HCl, any combination of these forms, pharmaceutical compositions thereof, and methods of treatment therewith.
Public/Granted literature
- US20110124869A1 Process for Preparing Modulators of Cystic Fibrosis Transmembrane Conductance Regulator Public/Granted day:2011-05-26
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