Invention Grant
- Patent Title: Pyrrole end-capped bipyridine assay powder for selective detection of zinc ions and a process for the preparation thereof
- Patent Title (中): 用于选择性检测锌离子的吡咯封端联吡啶测定粉末及其制备方法
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Application No.: US12811008Application Date: 2008-06-13
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Publication No.: US08344150B2Publication Date: 2013-01-01
- Inventor: Ayyappanpillai Ajayaghosh , Sivaramapanicker Sreejith
- Applicant: Ayyappanpillai Ajayaghosh , Sivaramapanicker Sreejith
- Applicant Address: IN New Delhi
- Assignee: Council of Scientific & Industrial Research
- Current Assignee: Council of Scientific & Industrial Research
- Current Assignee Address: IN New Delhi
- Agency: Blank Rome LLP
- Priority: IN2748/DEL/2007 20071228
- International Application: PCT/IN2008/000374 WO 20080613
- International Announcement: WO2009/084007 WO 20090709
- Main IPC: C07D401/00
- IPC: C07D401/00

Abstract:
The present invention provides pyrrole end-capped bipyridine derivative having a general formula (1) useful for the detection of zinc ions in solution. The present invention also provides a process for the preparation of pyrrole end-capped bipyridine derivative having a general formula (1). The present invention further provides a dipstick device by coating the assay powder of formula (1) in alumina over a thermoplastic or a glass solid support. The detection event can be monitored by noting the color change and the intense fluorescence change on the surface of the dipstick. For zinc ions, in addition to the color change an intense fluorescence change from greenish-yellow to red is observed. Detection event by means of fluorescence change is selective for Zn2+ ions when compared with all other biologically important metal ions like Na+, K+, Ca2+; Mg2+, Cu2+. The present dipstick is reusable, and can conduct the analysis of different samples using same stick.
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