A method for express execution of multimedia playing with device group activation is provided. A device activation group table is provided to a multimedia computer system. The device activation group table defines, according to the functional features of each multimedia players connected to the computer, each hot key and its associated multimedia player, driver, and application program. To execute the express activation of the group function menu, the method includes the following steps: detecting the depression of a hot key; computer loading and executing the driver for the multimedia player associated with the depressed hot key in the computer by referring to the device activation group table; and loading and executing the application program for the multimedia player associated with the depressed hot key to activate the associated multimedia player. For those multimedia players associated with the hot keys that are not depressed, no action is taken.