A method and system for using a graphics processing unit (“GPU”) frame buffer in a multi-GPU computing device as cache memory are disclosed. Specifically, one embodiment of the present invention sets forth a method, which includes the steps of designating a first GPU subsystem in the multi-GPU computing device as a rendering engine, designating a second GPU subsystem in the multi-GPU computing device as a cache accelerator, and directing an upstream memory access request associated with an address from the first GPU subsystem to a port associated with a first address range, wherein the address falls within the first address range. The first and the second GPU subsystems include a first GPU and a first frame buffer and a second GPU and a second frame buffer, respectively.