Systems and methods for scheduling wireless communications of a base station with multiple user mobile stations involve grouping the user mobile stations in clusters based on a predetermined criterion, such as a Quality of Service (QOS) profile of a user mobile station. Each cluster is assigned with a cluster weight factor that defines a priority level of the cluster. For each user mobile station in each cluster, a priority index may be determined based on the cluster weight factor of a respective cluster, and throughput and fairness factors respectively selected to maximize throughput and provide fairness to user mobile stations. The user mobile stations may be served in an order based on their priority indexes.