In a method for detecting a signal in a multi-input multi-output wireless communication system that receives signals transmitted through a plurality of transmission antennas by using a plurality of reception antennas, a detection order for detecting the transmission signals received through the reception antennas is determined on the basis of a cofactor determinant of components constituting a channel matrix representing characteristics of channels between the transmission antennas and the reception antennas. In addition, the transmission signal is detected from the signals received through the reception antennas in accordance with the determined detection order.