A fuel assembly for a pressurized water nuclear reactor contains a multiplicity of fuel rods which are guided in a plurality of axially spaced spacers which in each case form a square grid, composed of grid webs, with a multiplicity of cells arranged in rows and columns. In each case one control rod guide tube is guided through a number of these cells. At least one spacer is configured to be mechanically stronger in a first partial region than in a second partial region. In this second partial region, the spacer is provided with at least one resisting element which protrudes into a flow sub-channel formed between the fuel rods and increases the flow resistance. The resisting element counteracts a reduction associated with the mechanically weaker configuration, in the flow resistance in the second partial region and in this manner effects a homogenization of the hydraulic behavior of a spacer which is mechanically inhomogeneous on account of the varying mechanical configuration.