A method and system facilitate inter-cell interference cancellation in a wireless network. An RNTI component manages a set of radio network temporary identifiers (RNTIs) for a plurality of user equipment (UE). The RNTI component determines whether the UEs will likely cause interference with a neighboring cell and/or experience interference from a neighboring cell, based on a respective attribute of the UEs. The RNTI component includes a space splitting component that divides the set of RNTIs into at least two subsets based on the determination, and allocates a first group of the UEs that are determined to likely cause interference and/or experience interference to a first subset of the divided RNTIs, such that the UEs in the first group are allocated a corresponding one of the RNTIs among the first subset of RNTIs. An implicit broadcast component can implicitly broadcast the first subset of RNTIs to facilitate cancellation of interference possibly caused by the first group of UEs.