Methods and systems for coexistence in a multiband, multistandard communication system utilizing a plurality of phase locked loops (PLLs) are disclosed. Aspects may include determining one or more desired frequencies of operation of a transceiver, determining a frequency of unwanted signals such as spurs, intermodulation, and/or mixing product signals, and configuring the PLLs to operate at a multiple of the desired frequencies while avoiding the unwanted signals. The desired frequencies may be generated utilizing integer, which may include multi-modulus dividers. The wireless standards may include LTE, GSM, EDGE, GPS, Bluetooth, WiFi, and/or WCDMA, for example. The frequencies may be configured to mitigate interference. PLLs may be shared when operating in TDD mode, and used separately operating in FDD mode. One or more digital interface signals, zero exceptions on a transmitter spur emission mask, and sampling clocks for ADCs and/or DACs in the transceiver may be generated utilizing the PLLs.