Methods, systems, and computer program products for silence insertion descriptor (SID) conversion are disclosed. According to one aspect, the subject matter described herein includes a method for silence insertion descriptor (SID) conversion. The method includes receiving a wireless frame, the frame identifying a first node as a frame source and a second node as a frame destination; determining whether tandem-free operation (TFO) is applicable; responsive to a determination that TFO is applicable, determining whether the frame is a SID frame; responsive to a determination that the frame is a SID frame, determining whether the SID format used by the first node is incompatible with the SID format used by the second node; and responsive to a determination that the SID format used by the first node is incompatible with the SID format used by the second node, converting the SID frame from the SID format used by the first node to the SID format used by the second node.