A health monitoring system for a vehicle system includes an operational support system including a plurality of managers and a decision support module. Each manager corresponds to a different sub-system of the vehicle system, and comprises a plurality of reasoners and a fusion block. Each reasoner is configured to obtain data and provide preliminary output regarding a different component of the sub-system based on the data. The fusion block is coupled to the plurality of reasoners, and is configured to receive the preliminary output and generating manager output based on the preliminary output. The decision support module is coupled to the plurality of managers, and is configured to receive the manager output and provide a decision support output based on the manager output.