Invention Grant
US08350039B2 Substituted isoquinoline derivatives, pharmaceutical compositions, and methods of use as beta-secretase inhibitors
失效
取代的异喹啉衍生物，药物组合物和用作β-分泌酶抑制剂的方法
- Patent Title: Substituted isoquinoline derivatives, pharmaceutical compositions, and methods of use as beta-secretase inhibitors
- Patent Title (中): 取代的异喹啉衍生物，药物组合物和用作β-分泌酶抑制剂的方法
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Application No.: US13214434Application Date: 2011-08-22
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Publication No.: US08350039B2Publication Date: 2013-01-08
- Inventor: Adnan M. M. Mjalli , Bapu Gaddam , Devi Reddy Gohimukkula , Dharma Rao Polisetti , Hassan El Abdellaoui , Mohan Rao , Pingzhen Wang , Robert Carl Andrews , Rongyuan Xie , Tan Ren
- Applicant: Adnan M. M. Mjalli , Bapu Gaddam , Devi Reddy Gohimukkula , Dharma Rao Polisetti , Hassan El Abdellaoui , Mohan Rao , Pingzhen Wang , Robert Carl Andrews , Rongyuan Xie , Tan Ren
- Applicant Address: US NC High Point
- Assignee: High Point Pharmaceuticals, LLC
- Current Assignee: High Point Pharmaceuticals, LLC
- Current Assignee Address: US NC High Point
- Agent Samuel B. Rollins
- Main IPC: C07D217/26
- IPC: C07D217/26 ; A61K31/472 ; A61K31/4725 ; A61P25/28
Abstract:
The present invention is directed to substituted isoquinoline derivatives, pharmaceutically acceptable salts thereof, and tautomers of such compounds or salts, that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which BACE is involved.
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