Invention Grant
- Patent Title: 2-anilino-4-(heterocyclic)amino-pyrimidines
- Patent Title (中): 2-苯胺基-4-（杂环）氨基 - 嘧啶
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Application No.: US12465704Application Date: 2009-05-14
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Publication No.: US08354407B2Publication Date: 2013-01-15
- Inventor: Jane Far-Jine Djung , Adam Golebiowski , Jack A. Hunter , Gary P. Schrum
- Applicant: Jane Far-Jine Djung , Adam Golebiowski , Jack A. Hunter , Gary P. Schrum
- Applicant Address: DE Ingelheim am Rhein
- Assignee: Boehringer Ingelheim International GmbH
- Current Assignee: Boehringer Ingelheim International GmbH
- Current Assignee Address: DE Ingelheim am Rhein
- Agent Michael P. Morris; Usha R. Patel; David A. Dow
- Main IPC: C07D239/48
- IPC: C07D239/48 ; C07D413/06 ; C07D413/14 ; A61K31/505 ; A61K31/5355 ; A61P9/04
Abstract:
The present invention relates to 2-arylamino-4-(heterocyclic)aminopyrimidines inhibitors which are inhibitors and therefore inhibit Protein Kinase C-alpha (PKC-α). The PKC-α inhibitors of the present invention are important for improving myocardial intracellular calcium cycling, resulting in improved myocardial contraction and relaxation performance and thereby slowing the progression of heart failure. The present invention further relates to compositions comprising said 2-arylamino-4-(heterocyclic)amino-pyrimidines and to methods for controlling, abating, or otherwise slowing the progression of heart failure.
Public/Granted literature
- US20090227586A1 2-ANILINO-4-(HETEROCYCLIC)AMINO-PYRIMIDINES Public/Granted day:2009-09-10
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