Invention Grant
- Patent Title: Peptide binding to methylated DNA
- Patent Title (中): 肽结合甲基化DNA
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Application No.: US13502272Application Date: 2010-10-15
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Publication No.: US08354497B2Publication Date: 2013-01-15
- Inventor: Akimitsu Okamoto , Akiko Nomura
- Applicant: Akimitsu Okamoto , Akiko Nomura
- Applicant Address: JP Wako-shi, Saitama
- Assignee: Riken
- Current Assignee: Riken
- Current Assignee Address: JP Wako-shi, Saitama
- Agency: Leydig, Voit & Mayer, Ltd.
- Priority: JP2009-239657 20091016
- International Application: PCT/JP2010/068194 WO 20101015
- International Announcement: WO2011/046214 WO 20110421
- Main IPC: C07K14/00
- IPC: C07K14/00
Abstract:
The present invention aims to provide a tool etc. capable of detecting a methylated region of a DNA in a short time, in a labor-saving manner and without being limited by nucleotide sequences, and further capable of quantifying the methylation. The present invention provides a peptide containing a metal finger motif and a tyrosine derivative in a helix forming part of the motif, which recognizes and binds to a methylated region of a double stranded DNA.
Public/Granted literature
- US20120238038A1 PEPTIDE BINDING TO METHYLATED DNA Public/Granted day:2012-09-20
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