Invention Grant
- Patent Title: CD4 mimic peptides and their uses
- Patent Title (中): CD4模拟肽及其用途
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Application No.: US12304485Application Date: 2007-05-09
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Publication No.: US08354498B2Publication Date: 2013-01-15
- Inventor: Claudio Vita , Loïc Martin , François Stricher , Anne Descours , Laurence Morellato
- Applicant: Loïc Martin , François Stricher , Anne Descours , Laurence Morellato , Mireille Sauvage-Vita , Fabio Vita , Elena Vita
- Applicant Address: FR Paris
- Assignee: Commissariat a l'Energie Atomique
- Current Assignee: Commissariat a l'Energie Atomique
- Current Assignee Address: FR Paris
- Agency: Alston and Bird LLP
- Priority: WOPCT/IB2006/002332 20060613
- International Application: PCT/IB2007/002686 WO 20070509
- International Announcement: WO2008/010088 WO 20080124
- Main IPC: C07K14/73
- IPC: C07K14/73
Abstract:
An isolated peptide comprising the sequence (I): TPA-Asn-Leu-His-Phe-Cys-Gln-Leu-Xaaa-Cys-Lys-Ser-Leu-Gly-Leu-Leu-Gly-Arg-Cys-Xaab-Xaac-Xaad-Xaae-Cys-Ala-Cys-Val-NH2, wherein: TPA represents thiopropionic acid; Xaaa represents Arg, Lys; Xaab represents Ala, Arg; Xaac represents a D-amino acid; Xaad represents Thr, Ser, Asn; Xaae represents phenylalanine or a phenylalanine derivative having the structure (II), where A is absent or represents S, O, NH or CH2, B is absent or represents a C1 to C6 branched or straight-chain alkyl, and R represents a C3 to C6 alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, cycloalkenyl, cycloheterocyloalkenyl, aryl, or heteroaryl, and the use of the peptide for manufacturing anti-HIV therapeutic or vaccine compositions are disclosed herein.
Public/Granted literature
- US20090285798A1 CD4 MIMIC PEPTIDES AND THEIR USES Public/Granted day:2009-11-19
Information query
