Invention Grant
- Patent Title: Antibodies to human programmed death receptor PD-1
- Patent Title (中): 人类程序性死亡受体PD-1的抗体
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Application No.: US12663950Application Date: 2008-06-13
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Publication No.: US08354509B2Publication Date: 2013-01-15
- Inventor: Gregory John Carven , Hans van Eenennaam , Gradus Johannes Dulos
- Applicant: Gregory John Carven , Hans van Eenennaam , Gradus Johannes Dulos
- Applicant Address: NL AB Oss
- Assignee: MSD Oss B.V.
- Current Assignee: MSD Oss B.V.
- Current Assignee Address: NL AB Oss
- International Application: PCT/US2008/007463 WO 20080613
- International Announcement: WO2008/156712 WO 20081224
- Main IPC: C07K16/00
- IPC: C07K16/00
Abstract:
Antibodies which block the binding of human Programmed Death Receptor 1 (hPD-1) to its ligands (hPD-L1 or hPD-L2) and their variable region sequences are disclosed. A method of increasing the activity (or reducing downmodulation) of an immune response through the PD-I pathway is also disclosed.
Public/Granted literature
- US20100266617A1 ANTIBODIES TO HUMAN PROGRAMMED DEATH RECEPTOR PD-1 Public/Granted day:2010-10-21
Information query
