Invention Grant
US08354530B2 Process for the synthesis of rosuvastatin calcium 有权
合成罗苏伐他汀钙的方法

  • Patent Title: Process for the synthesis of rosuvastatin calcium
  • Patent Title (中): 合成罗苏伐他汀钙的方法
  • Application No.: US11997070
    Application Date: 2006-07-26
  • Publication No.: US08354530B2
    Publication Date: 2013-01-15
  • Inventor: Marko Zlicar
  • Applicant: Marko Zlicar
  • Applicant Address: SI Ljubljana
  • Assignee: Lek Pharmaceuticals d. d
  • Current Assignee: Lek Pharmaceuticals d. d
  • Current Assignee Address: SI Ljubljana
  • Agency: Luedeka Neely Group, P.C.
  • Priority: SI200500220 20050728; SI200500311 20051110
  • International Application: PCT/EP2006/007388 WO 20060726
  • International Announcement: WO2007/017117 WO 20070215
  • Main IPC: C07D239/42
  • IPC: C07D239/42
Process for the synthesis of rosuvastatin calcium
Abstract:
Present invention represents process for the preparation of HMG-CoA reductase inhibitors, in particular rosuvastatin calcium introducing L-malic acid as the source of chirality for the side chain.
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