An apparatus and method for resource management in a wireless communication system are provided. The method includes allocating resources and transmit power to maximize Quality of Service (QoS) satisfaction of User Equipments (UEs) and a sum rate using long-term channel information of the UEs, determining a transmit power constraint per resource block using a power distribution of the resources and transmit power allocation results and control information of at least one neighboring BS, and allocating resource and transmit power to maximize the QoS satisfaction of the UEs and the sum rate using short-term channel information of the UEs under a condition of the transmit power constraint.