A method, system and user interface for synthetic image generation for magnetic resonance (MR) imaging is described. A plurality of MR imaging data sets is received, each data set being acquired at a different value for a MR acquisition parameter. A response value for a particular property of tissues is determined, based on a calculated fit of each pixel to a property response model. A synthetic image is generated for a selected value of the MR acquisition parameter, based on the determined response value. An option is provided to dynamically change the selected value of the MR acquisition parameter and the synthetic image is re-generated for the changed value. An option may be provided to dynamically change the value. Another option may be provided to calculate a reliability measure for the synthetic image.