Methods and systems for controlling operation of a wind turbine. The method may comprise determining an alarm level for at least one component of the wind turbine. In the case that an alarm level for at least one component exceeds a predefined level, the method comprises estimating an expected remaining lifetime for the component under the current operating conditions, and controlling operation of the wind turbine in order to adjust the expected remaining lifetime for the component to a desired expected remaining lifetime for said component. Thereby, the expected remaining lifetime for the component can be prolonged until the next scheduled service event. Downtime of the wind turbine is considerably reduced, and unscheduled service events are avoided to the greatest possible extent. Mean time between inspections (MTBI) is also extended.