A method for prioritizing review of items may include: 1) identifying a first group of items to be reviewed for relevance to a particular matter; 2) during a review of the first group of items, tracking a proportion of items from the first group that are indicated as being relevant; 3) determining a relevance trend for the first group of items that indicates a rate at which the proportion of items from the first group that are indicated as being relevant is changing as the review of the first group of items progresses; 4) using the relevance trend for the first group of items to prioritize the review of the first group of items. Various other methods, systems, and computer-readable media are also disclosed herein.