Systems and methods are disclosed for dynamic management of workloads in clusters. In one embodiment, the system comprises a first cluster comprising a first plurality of nodes, each node of the first plurality of nodes including a first application, and a first load balancer to route transactions for the first application to one of the first plurality of nodes. The system also comprises a second cluster comprising a second plurality of nodes, each node of the second plurality of nodes including a second application, and a second load balancer to route transactions for the second application to one of the second plurality of nodes. One or more intersecting nodes are included in the first and second plurality of nodes, each intersecting node including one or more workload managers to dynamically allocate one or more computer resources to the first application and the second application.