A surgical instrument includes a handle and an elongated shaft that defines a longitudinal axis. An end effector extends from the elongated shaft and defines an end effector axis. The elongated shaft includes an articulating portion that both pivotally and rotationally movable with respect to the longitudinal axis. The end effector is rotationally movable with respect to the end effector axis. A drive mechanism includes at least one actuator disposed on the handle that is operable to move the end effector in at least three independent modes relative to the longitudinal axis or the end effector axis. The three modes include an articulation mode wherein the articulating portion of the elongated shaft pivots relative to the longitudinal axis, a shoulder roll mode wherein the articulating portion of the elongated shaft rotates about the longitudinal axis, and a wrist roll mode wherein the end effector rotates about the end effector axis.