A sample entry device is provided comprising a single plug-in site for automated input of medical samples, typically samples of body fluids, or quality control media, from diverse sample vessels. Sample transport containers are provided in the entry device, each having a cannula that can be inserted both through an opening into an open sample vessel and through a penetrable lid element into a closed sample vessel, and the entry device is provided with guiding elements, which will grip the cannula of the sample transport container to guide and center the cannula before it is inserted into the sample vessel or punctures it.