Invention Grant
- Patent Title: Method of identifying improved conjugates of biologically active compounds
- Patent Title (中): 识别生物活性化合物改良缀合物的方法
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Application No.: US12157937Application Date: 2008-06-12
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Publication No.: US08357506B2Publication Date: 2013-01-22
- Inventor: Michael Burnet , Jan-Hinrich Guse , Gene Kim , Albert Beck , Georgia Tsotsou , Irina Droste-Borel , Laurence Barker , Michael Wolff , Hans-Jurgen Gutke
- Applicant: Michael Burnet , Jan-Hinrich Guse , Gene Kim , Albert Beck , Georgia Tsotsou , Irina Droste-Borel , Laurence Barker , Michael Wolff , Hans-Jurgen Gutke
- Agency: Edwards Wildman Palmer LLP
- Agent Jeffrey D. Hsi; Mark D. Russett
- Main IPC: C12Q1/02
- IPC: C12Q1/02
Abstract:
This invention features a method of identifying a compound useful for enhancing efficacy of a therapeutic agent. The method includes incubating a compound in blood cells; separating immune cells from erythrocytic cells; and determining the ratio of the concentration of the compound in the immune cells to the concentration of the compound in the erythrocytic cells; wherein the compound comprises a transportophore and a therapeutic agent, in which the transportophore is covalently bonded to the therapeutic agent via a bond or a linker.
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