Invention Grant
- Patent Title: Methods of gene amplification and expression
- Patent Title (中): 基因扩增和表达方法
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Application No.: US12593132Application Date: 2008-03-27
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Publication No.: US08357514B2Publication Date: 2013-01-22
- Inventor: Alahari Arunakumari , Xiao-Ping Dai , Haile Ghebramariam
- Applicant: Alahari Arunakumari , Xiao-Ping Dai , Haile Ghebramariam
- Applicant Address: US NJ Princeton
- Assignee: Medarex, Inc.
- Current Assignee: Medarex, Inc.
- Current Assignee Address: US NJ Princeton
- Agent Z. Angela Guo
- International Application: PCT/US2008/058436 WO 20080327
- International Announcement: WO2008/121711 WO 20081009
- Main IPC: C12P21/06
- IPC: C12P21/06 ; C12N15/63
Abstract:
Disclosed are methods relating to amplification and expression of a nucleic acid sequence encoding a polypeptide of interest in recombinant cells, and cell lines and polypeptides produced from such methods. The methods disclosed herein permit the amplification of cell lines that express a polypeptide of interest in a relatively short period of time through the use of a bioreactor.
Public/Granted literature
- US20100178673A1 Methods of Gene Amplification and Expression Public/Granted day:2010-07-15
Information query
