Invention Grant
- Patent Title: Preparation of inactivated artificial antigen presenting cells and their use in cell therapies
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Application No.: US13350085Application Date: 2012-01-13
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Publication No.: US08357533B2Publication Date: 2013-01-22
- Inventor: Zeling Cai , Ann Moriarty , Juli Degraw , Didier Leturcq , Wei-Xing Shi , Karen Kabat Stegman , Xilian Yue
- Applicant: Zeling Cai , Ann Moriarty , Juli Degraw , Didier Leturcq , Wei-Xing Shi , Karen Kabat Stegman , Xilian Yue
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica, N.V.
- Current Assignee: Janssen Pharmaceutica, N.V.
- Current Assignee Address: BE Beerse
- Agent Myra H. McCormack
- Main IPC: C12N5/10
- IPC: C12N5/10
Abstract:
Methods of processing inactivated artificial antigen presenting cells (aAPCs) and artificial antigen presenting cells with specificity for selected antigenic peptides are described, including their generation and use in cell therapy compositions comprising activated cytotoxic T lymphocytes. Inactivated aAPCs are advantageously generated through crosslinking, such as via a photoreaction involving a psoralen derivative and UVA irradiation.
Public/Granted literature
- US20120115223A1 PREPARATION OF INACTIVATED ARTIFICIAL ANTIGEN PRESENTING CELLS AND THEIR USE IN CELL THERAPIES Public/Granted day:2012-05-10
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