Invention Grant
- Patent Title: 4-arylazo-3,5-diamino-pyrazole compounds and use thereof
- Patent Title (中): 4-芳基偶氮-3,5-二氨基 - 吡唑化合物及其用途
-
Application No.: US11661003Application Date: 2005-09-01
-
Publication No.: US08357673B2Publication Date: 2013-01-22
- Inventor: Petr Cankar , Iveta Frysova , Vladimir Krystof , Rene Lenobel , Jan Slouka , Miroslav Strnad , Peter Martin Fischer
- Applicant: Petr Cankar , Iveta Frysova , Vladimir Krystof , Rene Lenobel , Jan Slouka , Miroslav Strnad , Peter Martin Fischer
- Applicant Address: CZ Olomouc
- Assignee: Univerzita Palackeho V Olomouci
- Current Assignee: Univerzita Palackeho V Olomouci
- Current Assignee Address: CZ Olomouc
- Agency: Nelson Mullins Riley & Scarborough LLP
- Agent Cynthia L. Kanik
- Priority: GB0419416.3 20040901
- International Application: PCT/GB2005/003383 WO 20050901
- International Announcement: WO2006/024858 WO 20060309
- Main IPC: A61K31/655
- IPC: A61K31/655 ; A61P35/00 ; A61P35/02 ; C07D231/38 ; C07D403/12
Abstract:
A series of mono- and binuclear 4-arylazo-3,5-diamino-pyrazoles which are useful for inhibition of cyclin-dependent kinases (preferably CDK9). Hence they can be used as antimitotic-, pro-apoptotic and antiinflammatory drugs, in particular, in chemotherapy of cancer and asthma, therapy of psoriasis and parasitoses as those caused by fungi or protists, treatment of Alzheimer's disease or as antineurodegenerative drugs, or to suppress immunostimulation. These compounds are useful in a variety of utilities, including as intermediates in the preparation of flame-retardants, diagnostic reagents and therapeutics, including antivirals and immunosuppressors.
Public/Granted literature
- US20080312238A1 4-Arylazo-3,5-Diamino-Pyrazole Compounds and Use Thereof Public/Granted day:2008-12-18
Information query
