Invention Grant
- Patent Title: Isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
- Patent Title (中): 用于制备顺式吖啶及其相关中间体的异喹啉鎓化合物
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Application No.: US12598378Application Date: 2008-05-01
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Publication No.: US08357807B2Publication Date: 2013-01-22
- Inventor: Vladimir Naddaka , Shen Jingshan , Oded Arad , Guo Hongli , Ofer Sharon , Eyal Klopfer , Shady Saeed
- Applicant: Vladimir Naddaka , Shen Jingshan , Oded Arad , Guo Hongli , Ofer Sharon , Eyal Klopfer , Shady Saeed
- Applicant Address: IL Bnei Brak
- Assignee: CHEMAGIS Ltd.
- Current Assignee: CHEMAGIS Ltd.
- Current Assignee Address: IL Bnei Brak
- Agency: Leydig, Voit & Mayer, Ltd.
- International Application: PCT/IL2008/000586 WO 20080501
- International Announcement: WO2008/132746 WO 20081106
- Main IPC: C07D217/16
- IPC: C07D217/16
Abstract:
The present invention provides novel isoquinolinium compounds, methods of producing the isoquinolinium compounds, and methods for converting them into cisatracurium, e.g., cisatracurium besylate. The isoquinolinium compounds of the present invention can be obtained in the form of solids, which can be purified using simple techniques and can be used to afford pure cisatracurium besylate without HPLC purification.
Public/Granted literature
- US20100168431A1 NOVEL ISOQUINOLINIUM COMPOUNDS USEFUL IN THE PREPARATION OF CISATRACURIUM AND ASSOCIATED INTERMEDIATES Public/Granted day:2010-07-01
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