Invention Grant
US08357819B2 Method for the synthesis of (Z)-3-[2-butoxy-3′-(3-heptyl-1-methyl-ureido)-biphenyl-4-yl]-2-methoxy-acrylic acid
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合成（Z）-3- [2-丁氧基-3' - （3-庚基-1-甲基 - 脲基） - 联苯-4-基] -2-甲氧基 - 丙烯酸的方法
![Method for the synthesis of (Z)-3-[2-butoxy-3′-(3-heptyl-1-methyl-ureido)-biphenyl-4-yl]-2-methoxy-acrylic acid](/docs/US/2013-01-22/US08357819B2/abs.jpg.600x600.jpg)
- Patent Title: Method for the synthesis of (Z)-3-[2-butoxy-3′-(3-heptyl-1-methyl-ureido)-biphenyl-4-yl]-2-methoxy-acrylic acid
- Patent Title (中): 合成（Z）-3- [2-丁氧基-3' - （3-庚基-1-甲基 - 脲基） - 联苯-4-基] -2-甲氧基 - 丙烯酸的方法
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Application No.: US12599647Application Date: 2008-04-18
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Publication No.: US08357819B2Publication Date: 2013-01-22
- Inventor: Jean-Guy Boiteau
- Applicant: Jean-Guy Boiteau
- Applicant Address: FR Biot
- Assignee: Galderma Research & Development
- Current Assignee: Galderma Research & Development
- Current Assignee Address: FR Biot
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- Priority: FR0755021 20070511
- International Application: PCT/FR2008/050706 WO 20080418
- International Announcement: WO2008/139121 WO 20081120
- Main IPC: C07C273/18
- IPC: C07C273/18 ; C07C309/65 ; C07C309/73 ; C07C309/63 ; C07C69/732
![Method for the synthesis of (Z)-3-[2-butoxy-3′-(3-heptyl-1-methyl-ureido)-biphenyl-4-yl]-2-methoxy-acrylic acid](/abs-image/US/2013/01/22/US08357819B2/abs.jpg.150x150.jpg)
Abstract:
The invention relates to a process for the synthesis of (Z)-3-[2-butoxy-3′-(3-heptyl-1-methylureido)biphenyl-4-yl]-2-methoxyacrylic acid of formula (I): and also to the process for the synthesis of the reaction intermediates of general formula (XII), and to the said compounds when R2 is chosen from the methyl, trifluoromethyl, phenyl and 4-tolyl radicals:
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