A mouse with a wire arrangement structure is provided. The mouse includes a housing, a base, a connection unit and a wire. The housing includes an opening and an opening edge. The base corresponds to the housing, wherein the base is moved between a first position and a second position, and when the base is in the first position, the base abuts the opening edge to cover the opening, and when the base is in the second position, the base is separated from the opening edge. The connection unit is connected to the housing and the base, allowing the base to move relative to the housing. The wire includes a joint, wherein when the wire is in a receiving state, the wire is wound up around the connection unit.