Techniques for synchronizing a receiver and transmitter in a wireless communication system address synchronization within the context of a detection formulation and provide synchronization statistics used to declare a synchronization detection. A signal is received from a channel at multiple receiving antennas. The receiver and transmitter are synchronized based on the received signal and a channel model incorporating the multiple receiving antennas. The channel model may also incorporate a resolvable delay spread of the received signal with respect to each receiving antenna. Synchronization may be based on a known component of a received signal and further on a channel model incorporating multiple receiving antennas and an interference signal. The known component may be a cyclic prefix or a pilot sequence as in orthogonal frequency division multiplexing (OFDM).